Moving into the second semester of Organic Chemistry
  • Successful completion of the first term of Organic Chemistry means you should have a basic handle on what structures are possible, what constitutes reactivity and stability, and which pathways are open to organic molecules when they react.
  • The second semester continues the discussion of the important functional groups while expanding the toolbox of useful synthetic transformations and the scope of mechanistic possibilities.
  • To be successful in the second term it is essential that the student know the basics from the first semester. Below is a series of the most important mechanisms studied previously, the features of which show up repeatedly in the second half of the course.
  • The last two mechanisms, reactions of carbonyl groups with organometallic Grignard reagents, are important pathways that are studied in the first month of the second semester and which represent crucial C-C bond-making protocols.
Acid-Base reactions
Unimolecular Substitution in acid
Bimolecular Substitution in acid
Unimolecular Elimination in acid
Acid-catalyzed Hydration of an Alkene
Nucleophilic Addition of Grignard reagent to Aldehyde
Nucleophilic Acyl Substitution & Addition of Grignard with Ester